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Structure Based Prediction of Subtype-Selectivity for Adenosine Receptor Antagonists
One of the major hurdles in the development of safe and effective drugs targeting G-protein coupled receptors (GPCRs) is finding ligands that are highly selective for a specific receptor subtype. Structural understanding of subtype-specific binding pocket variations and ligand-receptor interactions...
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| Main Authors: | , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2010
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2980563/ https://ncbi.nlm.nih.gov/pubmed/20637786 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2010.07.009 |
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