Sodium Ion Binding Pocket Mutations and Adenosine A(2A) Receptor Function

Recently we identified a sodium ion binding pocket in a high-resolution structure of the human adenosine A(2A) receptor. In the present study we explored this binding site through site-directed mutagenesis and molecular dynamics simulations. Amino acids in the pocket were mutated to alanine, and the...

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Bibliografske podrobnosti
izdano v:Mol Pharmacol
Main Authors: Massink, Arnault, Gutiérrez-de-Terán, Hugo, Lenselink, Eelke B., Ortiz Zacarías, Natalia V., Xia, Lizi, Heitman, Laura H., Katritch, Vsevolod, Stevens, Raymond C., IJzerman, Adriaan P.
Format: Artigo
Jezik:Inglês
Izdano: The American Society for Pharmacology and Experimental Therapeutics 2015
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Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6067640/
https://ncbi.nlm.nih.gov/pubmed/25473121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.114.095737
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