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In search of novel ligands using a structure-based approach: a case study on the adenosine A(2A) receptor

In this work, we present a case study to explore the challenges associated with finding novel molecules for a receptor that has been studied in depth and has a wealth of chemical information available. Specifically, we apply a previously described protocol that incorporates explicit water molecules...

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Detalhes bibliográficos
Publicado no:J Comput Aided Mol Des
Main Authors: Lenselink, Eelke B., Beuming, Thijs, van Veen, Corine, Massink, Arnault, Sherman, Woody, van Vlijmen, Herman W. T., IJzerman, Adriaan P.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer International Publishing 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5083784/
https://ncbi.nlm.nih.gov/pubmed/27629350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10822-016-9963-7
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