Extrinsic Tryptophans as NMR Probes of Allosteric Coupling in Membrane Proteins: Application to the A(2A) Adenosine Receptor

Tryptophan indole (15)N–(1)H signals are well separated in nuclear magnetic resonance (NMR) spectra of proteins. Assignment of the indole (15)N–(1)H signals therefore enables one to obtain site-specific information on complex proteins in supramacromolecular systems, even when extensive assignment of...

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Vydáno v:J Am Chem Soc
Hlavní autoři: Eddy, Matthew T., Gao, Zhan-Guo, Mannes, Philip, Patel, Nilkanth, Jacobson, Kenneth A., Katritch, Vsevolod, Stevens, Raymond C., Wüthrich, Kurt
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6192543/
https://ncbi.nlm.nih.gov/pubmed/29874058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.8b03805
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