Extrinsic Tryptophans as NMR Probes of Allosteric Coupling in Membrane Proteins: Application to the A(2A) Adenosine Receptor

Tryptophan indole (15)N–(1)H signals are well separated in nuclear magnetic resonance (NMR) spectra of proteins. Assignment of the indole (15)N–(1)H signals therefore enables one to obtain site-specific information on complex proteins in supramacromolecular systems, even when extensive assignment of...

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發表在:J Am Chem Soc
Main Authors: Eddy, Matthew T., Gao, Zhan-Guo, Mannes, Philip, Patel, Nilkanth, Jacobson, Kenneth A., Katritch, Vsevolod, Stevens, Raymond C., Wüthrich, Kurt
格式: Artigo
語言:Inglês
出版: 2018
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6192543/
https://ncbi.nlm.nih.gov/pubmed/29874058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.8b03805
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