Extrinsic Tryptophans as NMR Probes of Allosteric Coupling in Membrane Proteins: Application to the A(2A) Adenosine Receptor

Tryptophan indole (15)N–(1)H signals are well separated in nuclear magnetic resonance (NMR) spectra of proteins. Assignment of the indole (15)N–(1)H signals therefore enables one to obtain site-specific information on complex proteins in supramacromolecular systems, even when extensive assignment of...

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Pubblicato in:J Am Chem Soc
Autori principali: Eddy, Matthew T., Gao, Zhan-Guo, Mannes, Philip, Patel, Nilkanth, Jacobson, Kenneth A., Katritch, Vsevolod, Stevens, Raymond C., Wüthrich, Kurt
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6192543/
https://ncbi.nlm.nih.gov/pubmed/29874058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.8b03805
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