Allosteric Coupling of Drug Binding and Intracellular Signaling in the A(2A) Adenosine Receptor

Signaling across cellular membranes, the 826 human G protein-coupled receptors (GPCR) govern a wide range of vital physiological processes, making GPCRs prominent drug targets. X-ray crystallography provided GPCR molecular architectures, which also revealed the need for additional structural dynamic...

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Publicado en:Cell
Autores principales: Eddy, Matthew T., Lee, Ming-Yue, Gao, Zhan-Guo, White, Kate L., Didenko, Tatiana, Horst, Reto, Audet, Martin, Stanczak, Pawel, McClary, Kyle M., Han, Gye Won, Jacobson, Kenneth A., Stevens, Raymond C., Wüthrich, Kurt
Formato: Artigo
Lenguaje:Inglês
Publicado: 2017
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5766378/
https://ncbi.nlm.nih.gov/pubmed/29290469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2017.12.004
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