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Harnessing Ion-Binding Sites for GPCR Pharmacology
Endogenous ions play important roles in the function and pharmacology of G-protein coupled receptors (GPCRs). Historically the evidence for ionic modulation of GPCR function dates to 1973 with studies of opioid receptors, where it was demonstrated that physiologic concentrations of sodium allosteric...
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| Publicado no: | Pharmacol Rev |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Pharmacology and Experimental Therapeutics
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6782022/ https://ncbi.nlm.nih.gov/pubmed/31551350 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/pr.119.017863 |
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