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Harnessing Ion-Binding Sites for GPCR Pharmacology

Endogenous ions play important roles in the function and pharmacology of G-protein coupled receptors (GPCRs). Historically the evidence for ionic modulation of GPCR function dates to 1973 with studies of opioid receptors, where it was demonstrated that physiologic concentrations of sodium allosteric...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Pharmacol Rev
Päätekijät: Zarzycka, Barbara, Zaidi, Saheem A., Roth, Bryan L., Katritch, Vsevolod
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: The American Society for Pharmacology and Experimental Therapeutics 2019
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6782022/
https://ncbi.nlm.nih.gov/pubmed/31551350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/pr.119.017863
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