Selectivity Challenges in Docking Screens for GPCR Targets and Antitargets

Por Weiss, Dahlia R., Karpiak, Joel, Huang, Xi-Ping, Sassano, Maria F., Lyu, Jiankun, Roth, Bryan L., Shoichet, Brian K.
Publicado no J Med Chem (2018)

Discovery of peptide inhibitors targeting human programmed death 1 (PD-1) receptor

Por Li, Qiao, Quan, Lina, Lyu, Jiankun, He, Zenghui, Wang, Xia, Meng, Jiajia, Zhao, Zhenjiang, Zhu, Lili, Liu, Xiaofeng, Li, Honglin
Publicado no Oncotarget (2016)

Structure-Guided Design of C4-alkyl-1,4-dihydro-2H-pyrimido[4,5-d][1,3]oxazin-2-ones as Potent and Mutant-Selective Epidermal Growth Factor Receptor (EGFR) L858R/T790M Inhibitors

Por Hao, Yongjia, Lyu, Jiankun, Qu, Rong, Sun, Deheng, Zhao, Zhenjiang, Chen, Zhuo, Ding, Jian, Xie, Hua, Xu, Yufang, Li, Honglin
Publicado no Sci Rep (2017)