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Structure and dynamics of PD-L1 and an ultra high-affinity PD-1 receptor mutant
The immune checkpoint receptor PD-1 and its ligand, PD-L1, have emerged as key regulators of anti-tumor immunity in humans. Recently, we reported an ultra high-affinity PD-1 mutant, termed HAC PD-1, which shows superior therapeutic efficacy in mice compared to antibodies. However, the molecular deta...
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| Publicado no: | Structure |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5052120/ https://ncbi.nlm.nih.gov/pubmed/27618663 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2016.06.026 |
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