Engineering high-affinity PD-1 variants for optimized immunotherapy and immuno-PET imaging

Signaling through the immune checkpoint programmed cell death protein-1 (PD-1) enables tumor progression by dampening antitumor immune responses. Therapeutic blockade of the signaling axis between PD-1 and its ligand programmed cell death ligand-1 (PD-L1) with monoclonal antibodies has shown remarka...

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Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Maute, Roy L., Gordon, Sydney R., Mayer, Aaron T., McCracken, Melissa N., Natarajan, Arutselvan, Ring, Nan Guo, Kimura, Richard, Tsai, Jonathan M., Manglik, Aashish, Kruse, Andrew C., Gambhir, Sanjiv S., Weissman, Irving L., Ring, Aaron M.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2015
Matèries:
PNAS Plus
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4664306/
https://ncbi.nlm.nih.gov/pubmed/26604307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1519623112
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