Engineering high-affinity PD-1 variants for optimized immunotherapy and immuno-PET imaging

Signaling through the immune checkpoint programmed cell death protein-1 (PD-1) enables tumor progression by dampening antitumor immune responses. Therapeutic blockade of the signaling axis between PD-1 and its ligand programmed cell death ligand-1 (PD-L1) with monoclonal antibodies has shown remarka...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Maute, Roy L., Gordon, Sydney R., Mayer, Aaron T., McCracken, Melissa N., Natarajan, Arutselvan, Ring, Nan Guo, Kimura, Richard, Tsai, Jonathan M., Manglik, Aashish, Kruse, Andrew C., Gambhir, Sanjiv S., Weissman, Irving L., Ring, Aaron M.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2015
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4664306/
https://ncbi.nlm.nih.gov/pubmed/26604307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1519623112
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