Covalent agonists for studying G protein-coupled receptor activation

Structural studies on G protein-coupled receptors (GPCRs) provide important insights into the architecture and function of these important drug targets. However, the crystallization of GPCRs in active states is particularly challenging, requiring the formation of stable and conformationally homogene...

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Dades bibliogràfiques
Autors principals: Weichert, Dietmar, Kruse, Andrew C., Manglik, Aashish, Hiller, Christine, Zhang, Cheng, Hübner, Harald, Kobilka, Brian K., Gmeiner, Peter
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2014
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4115510/
https://ncbi.nlm.nih.gov/pubmed/25006259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1410415111
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