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Covalent agonists for studying G protein-coupled receptor activation
Structural studies on G protein-coupled receptors (GPCRs) provide important insights into the architecture and function of these important drug targets. However, the crystallization of GPCRs in active states is particularly challenging, requiring the formation of stable and conformationally homogene...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4115510/ https://ncbi.nlm.nih.gov/pubmed/25006259 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1410415111 |
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