Covalent agonists for studying G protein-coupled receptor activation

Structural studies on G protein-coupled receptors (GPCRs) provide important insights into the architecture and function of these important drug targets. However, the crystallization of GPCRs in active states is particularly challenging, requiring the formation of stable and conformationally homogene...

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Bibliografski detalji
Glavni autori: Weichert, Dietmar, Kruse, Andrew C., Manglik, Aashish, Hiller, Christine, Zhang, Cheng, Hübner, Harald, Kobilka, Brian K., Gmeiner, Peter
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2014
Teme:
Biological Sciences
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4115510/
https://ncbi.nlm.nih.gov/pubmed/25006259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1410415111
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