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Role of Detergents in Conformational Exchange of a G Protein-coupled Receptor

The G protein-coupled β(2)-adrenoreceptor (β(2)AR) signals through the heterotrimeric G proteins G(s) and G(i) and β-arrestin. As such, the energy landscape of β(2)AR-excited state conformers is expected to be complex. Upon tagging Cys-265 of β(2)AR with a trifluoromethyl probe, (19)F NMR was used t...

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Bibliografische gegevens
Hoofdauteurs: Chung, Ka Young, Kim, Tae Hun, Manglik, Aashish, Alvares, Rohan, Kobilka, Brian K., Prosser, R. Scott
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Biochemistry and Molecular Biology 2012
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3476297/
https://ncbi.nlm.nih.gov/pubmed/22893704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.406371
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