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Negative selection and peptide chemistry determine the size of naïve foreign peptide-MHCII-specific CD4(+) T cell populations
Naïve CD4(+) T cell populations that express TCRs specific for different foreign peptide-MHCII (pMHCII) ligands can vary in size over several orders of magnitude. This variation may explain why immune responses to some peptides are stronger than others. Here we used a sensitive pMHCII-tetramer based...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3510669/ https://ncbi.nlm.nih.gov/pubmed/20861357 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1002276 |
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