T cell receptor cross-reactivity between similar foreign and self peptides influences naïve cell population size and autoimmunity

T cell receptor (TCR) cross-reactivity between major histocompatibility complex II (MHCII)-binding self and foreign peptides could influence the naïve CD4(+) T cell repertoire and autoimmunity. We found that nonamer peptides that bind to the same MHCII molecule only need to share five amino acids to...

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Detalhes bibliográficos
Publicado no:Immunity
Main Authors: Nelson, Ryan W., Beisang, Daniel, Tubo, Noah J., Dileepan, Thamotharampillai, Wiesner, Darin L., Nielsen, Kirsten, Wüthrich, Marcel, Klein, Bruce S., Kotov, Dmitri I., Spanier, Justin A., Fife, Brian T., Moon, James J., Jenkins, Marc K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4355167/
https://ncbi.nlm.nih.gov/pubmed/25601203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2014.12.022
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