T cell receptor cross-reactivity between similar foreign and self peptides influences naïve cell population size and autoimmunity

T cell receptor (TCR) cross-reactivity between major histocompatibility complex II (MHCII)-binding self and foreign peptides could influence the naïve CD4(+) T cell repertoire and autoimmunity. We found that nonamer peptides that bind to the same MHCII molecule only need to share five amino acids to...

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Publicado en:Immunity
Autores principales: Nelson, Ryan W., Beisang, Daniel, Tubo, Noah J., Dileepan, Thamotharampillai, Wiesner, Darin L., Nielsen, Kirsten, Wüthrich, Marcel, Klein, Bruce S., Kotov, Dmitri I., Spanier, Justin A., Fife, Brian T., Moon, James J., Jenkins, Marc K.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4355167/
https://ncbi.nlm.nih.gov/pubmed/25601203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2014.12.022
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