Naïve B cells with high-avidity germline-encoded antigen receptors produce persistent IgM(+) and transient IgG(+) memory B cells

Although immune memory often lasts for life, this is not the case for certain vaccines in some individuals. We sought a mechanism for this phenomenon by studying B cell responses to phycoerythrin (PE). PE immunization of mouse strains with Igh(b) immunoglobulin (Ig) variable heavy chain (V(H)) genes...

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Bibliographic Details
Published in:Immunity
Main Authors: Pape, Kathryn A., Maul, Robert W., Dileepan, Thamotharampillai, Paustian, Amanda Schmidt, Gearhart, Patricia J., Jenkins, Marc K.
Format: Artigo
Language:Inglês
Published: 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6052797/
https://ncbi.nlm.nih.gov/pubmed/29884459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2018.04.019
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