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CD28 Promotes CD4(+) T Cell Clonal Expansion During infection Independently of its YMNM and PYAP Motifs
CD28 is required for maximal proliferation of CD4(+) T cells stimulated through their TCRs. Two sites within the cytoplasmic tail of CD28, a YMNM sequence that recruits PI3K and activates NFκB, and a PYAP sequence that recruits Lck, are candidates as transducers of the signals responsible for these...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3464098/ https://ncbi.nlm.nih.gov/pubmed/22896637 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1103231 |
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