CD28 Promotes Plasma Cell Survival, Sustained Antibody Responses, and BLIMP-1 Upregulation through Its Distal PYAP Proline Motif

In health, long-lived plasma cells (LLPC) are essential for durable protective humoral immunity, and, conversely, in disease are a major source of pathogenic Abs in autoimmunity, graft rejection, and allergy. However, the molecular basis for their longevity is largely unknown. We have recently found...

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Detalhes bibliográficos
Publicado no:J Immunol
Main Authors: Rozanski, Cheryl H., Utley, Adam, Carlson, Louise M., Farren, Matthew R., Murray, Megan, Russell, Lisa M., Nair, Jayakumar R., Yang, ZhengYu, Brady, William, Garrett-Sinha, Lee Ann, Schoenberger, Stephen P., Green, Jonathan M., Boise, Lawrence H., Lee, Kelvin P.
Formato: Artigo
Idioma:Inglês
Publicado em: AAI 2015
Assuntos:
Immune Regulation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4416738/
https://ncbi.nlm.nih.gov/pubmed/25833397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1402260
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