Positive selection optimizes the number and function of MHCII-restricted CD4(+) T cell clones in the naive polyclonal repertoire

T cell receptors (TCRs) on T lymphocytes in an individual bind foreign peptides bound to major histocompatibility complex (MHC) molecules expressed in that individual (designated MHC(A)). Results from radiation bone marrow chimeras and TCR transgenic mice indicate that this complex form of antigen r...

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Detalhes bibliográficos
Main Authors: Chu, H. Hamlet, Moon, James J., Takada, Kensuke, Pepper, Marion, Molitor, Jerry A., Schacker, Timothy W., Hogquist, Kristin A., Jameson, Stephen C., Jenkins, Marc K.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2708705/
https://ncbi.nlm.nih.gov/pubmed/19541603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0902015106
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