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Allosteric activation of proto-oncogene kinase Src by GPCR–beta-arrestin complexes

G protein–coupled receptors (GPCRs) initiate signaling cascades via G-proteins and beta-arrestins (βarr). βarr-dependent actions begin with recruitment of βarr to the phosphorylated receptor tail and are followed by engagement with the receptor core. βarrs are known to act as adaptor proteins bindin...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Pakharukova, Natalia, Masoudi, Ali, Pani, Biswaranjan, Staus, Dean P., Lefkowitz, Robert J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7864071/
https://ncbi.nlm.nih.gov/pubmed/32978252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.015400
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