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Allosteric Modulation of β-Arrestin-biased Angiotensin II Type 1 Receptor Signaling by Membrane Stretch

It has recently been appreciated that the angiotensin II type 1 receptor (AT1R), a prototypic member of the G protein-coupled receptor superfamily, also functions as a mechanosensor. Specifically, mechanical stretch activates the AT1R to promote downstream signaling mediated exclusively by the multi...

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Hlavní autoři: Tang, Wei, Strachan, Ryan T., Lefkowitz, Robert J., Rockman, Howard A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2014
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4192482/
https://ncbi.nlm.nih.gov/pubmed/25170081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.585067
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