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Mechanoactivation of the angiotensin II type 1 receptor induces β-arrestin-biased signaling through Gα(i) coupling

Ligand activation of the angiotensin II type 1 receptor (AT1R), a member of the G protein-coupled receptor (GPCR) family, stimulates intracellular signaling to mediate a variety of physiological responses. The AT1R is also known to be a mechanical sensor. When activated by mechanical stretch, the AT...

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Bibliographic Details
Published in:J Cell Biochem
Main Authors: Wang, Jialu, Hanada, Kenji, Gareri, Clarice, Rockman, Howard A.
Format: Artigo
Language:Inglês
Published: 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5826900/
https://ncbi.nlm.nih.gov/pubmed/29231251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcb.26552
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