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Gα(i) is required for carvedilol-induced β(1) adrenergic receptor β-arrestin biased signaling
The β(1) adrenergic receptor (β(1)AR) is recognized as a classical Gα(s)-coupled receptor. Agonist binding not only initiates G protein-mediated signaling but also signaling through the multifunctional adapter protein β-arrestin. Some βAR ligands, such as carvedilol, stimulate βAR signaling preferen...
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| Publicado no: | Nat Commun |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5700200/ https://ncbi.nlm.nih.gov/pubmed/29167435 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01855-z |
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