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β-Blockers alprenolol and carvedilol stimulate β-arrestin-mediated EGFR transactivation
Recent evidence suggests that binding of agonist to its cognate receptor initiates not only classical G protein-mediated signaling, but also β-arrestin-dependent signaling. One such β-arrestin-mediated pathway uses the β(1)-adrenergic receptor (β(1)AR) to transactivate the EGFR. To determine whether...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2567217/ https://ncbi.nlm.nih.gov/pubmed/18787115 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0804745105 |
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