β-Blockers alprenolol and carvedilol stimulate β-arrestin-mediated EGFR transactivation

Recent evidence suggests that binding of agonist to its cognate receptor initiates not only classical G protein-mediated signaling, but also β-arrestin-dependent signaling. One such β-arrestin-mediated pathway uses the β(1)-adrenergic receptor (β(1)AR) to transactivate the EGFR. To determine whether...

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Main Authors: Kim, Il-Man, Tilley, Douglas G., Chen, Juhsien, Salazar, Natasha C., Whalen, Erin J., Violin, Jonathan D., Rockman, Howard A.
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2008
Ábhair:
Biological Sciences
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2567217/
https://ncbi.nlm.nih.gov/pubmed/18787115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0804745105
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