β-Arrestin–mediated β(1)-adrenergic receptor transactivation of the EGFR confers cardioprotection

Deleterious effects on the heart from chronic stimulation of β-adrenergic receptors (βARs), members of the 7 transmembrane receptor family, have classically been shown to result from G(s)-dependent adenylyl cyclase activation. Here, we identify a new signaling mechanism using both in vitro and in vi...

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Main Authors: Noma, Takahisa, Lemaire, Anthony, Naga Prasad, Sathyamangla V., Barki-Harrington, Liza, Tilley, Douglas G., Chen, Juhsien, Le Corvoisier, Philippe, Violin, Jonathan D., Wei, Huijun, Lefkowitz, Robert J., Rockman, Howard A.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2007
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1952636/
https://ncbi.nlm.nih.gov/pubmed/17786238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI31901
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