Gα(i) is required for carvedilol-induced β(1) adrenergic receptor β-arrestin biased signaling

The β(1) adrenergic receptor (β(1)AR) is recognized as a classical Gα(s)-coupled receptor. Agonist binding not only initiates G protein-mediated signaling but also signaling through the multifunctional adapter protein β-arrestin. Some βAR ligands, such as carvedilol, stimulate βAR signaling preferen...

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Publicat a:Nat Commun
Autors principals: Wang, Jialu, Hanada, Kenji, Staus, Dean P., Makara, Michael A., Dahal, Giri Raj, Chen, Qiang, Ahles, Andrea, Engelhardt, Stefan, Rockman, Howard A.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5700200/
https://ncbi.nlm.nih.gov/pubmed/29167435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01855-z
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