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G Protein-Coupled Receptor Biased Agonism
G protein-coupled receptors (GPCR) are the largest family of targets for current therapeutics. The classic model of their activation was binary, where agonist binding induced an active conformation and subsequent downstream signaling. Subsequently, the revised concept of biased agonism emerged, wher...
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| Veröffentlicht in: | J Cardiovasc Pharmacol |
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| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4783281/ https://ncbi.nlm.nih.gov/pubmed/26751266 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FJC.0000000000000356 |
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