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A Practical Guide to Approaching Biased Agonism at G Protein Coupled Receptors

Biased agonism, the ability of a receptor to differentially activate downstream signaling pathways depending on binding of a “biased” agonist compared to a “balanced” agonist, is a well-established paradigm for G protein-coupled receptor (GPCR) signaling. Biased agonists have the promise to act as s...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Front Neurosci
Prif Awduron: Gundry, Jaimee, Glenn, Rachel, Alagesan, Priya, Rajagopal, Sudarshan
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Frontiers Media S.A. 2017
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5258729/
https://ncbi.nlm.nih.gov/pubmed/28174517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2017.00017
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