β-arrestin Biased Allosteric Modulator of NTSR1 Selectively Attenuates Addictive Behaviors

Small molecule neurotensin receptor 1 (NTSR1) agonists have been pursued for more than 40 years as potential therapeutics for psychiatric disorders, including drug addiction. Clinical development of NTSR1 agonists has, however, been precluded by their severe side effects. NTSR1, a G protein-coupled...

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Detalhes bibliográficos
Publicado no:Cell
Main Authors: Slosky, Lauren M., Bai, Yushi, Toth, Krisztian, Ray, Caroline, Rochelle, Lauren K., Badea, Alexandra, Chandrasekhar, Rahul, Pogorelov, Vladimir M., Abraham, Dennis M., Atluri, Namratha, Peddibhotla, Satyamaheshwar, Hedrick, Michael P., Hershberger, Paul, Maloney, Patrick, Yuan, Hong, Li, Zibo, Wetsel, William C., Pinkerton, Anthony B., Barak, Lawrence S., Caron, Marc G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7466280/
https://ncbi.nlm.nih.gov/pubmed/32470395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2020.04.053
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