β-arrestin Biased Allosteric Modulator of NTSR1 Selectively Attenuates Addictive Behaviors

Small molecule neurotensin receptor 1 (NTSR1) agonists have been pursued for more than 40 years as potential therapeutics for psychiatric disorders, including drug addiction. Clinical development of NTSR1 agonists has, however, been precluded by their severe side effects. NTSR1, a G protein-coupled...

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Dades bibliogràfiques
Publicat a:Cell
Autors principals: Slosky, Lauren M., Bai, Yushi, Toth, Krisztian, Ray, Caroline, Rochelle, Lauren K., Badea, Alexandra, Chandrasekhar, Rahul, Pogorelov, Vladimir M., Abraham, Dennis M., Atluri, Namratha, Peddibhotla, Satyamaheshwar, Hedrick, Michael P., Hershberger, Paul, Maloney, Patrick, Yuan, Hong, Li, Zibo, Wetsel, William C., Pinkerton, Anthony B., Barak, Lawrence S., Caron, Marc G.
Format: Artigo
Idioma:Inglês
Publicat: 2020
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7466280/
https://ncbi.nlm.nih.gov/pubmed/32470395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2020.04.053
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