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Allosteric Nanobodies Reveal the Dynamic Range and Diverse Mechanisms of GPCR Activation
G-protein coupled receptors (GPCRs) modulate many physiological processes by transducing a variety of extracellular cues into intracellular responses. Ligand binding to an extracellular orthosteric pocket propagates conformational change to the receptor cytosolic region to promote binding and activa...
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Publicado no: | Nature |
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Main Authors: | , , , , , , , , , , , , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2016
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4961583/ https://ncbi.nlm.nih.gov/pubmed/27409812 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature18636 |
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