Noncanonical scaffolding of G(αi) and β-arrestin by G protein–coupled receptors

Heterotrimeric guanine nucleotide–binding protein (G protein)–coupled receptors (GPCRs) are common drug targets and canonically couple to specific G(α) protein subtypes and β-arrestin adaptor proteins. G protein–mediated signaling and β-arrestin–mediated signaling have been considered separable. We...

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Udgivet i:Science
Main Authors: Smith, Jeffrey S., Pack, Thomas F., Inoue, Asuka, Lee, Claudia, Zheng, Kevin, Choi, Issac, Eiger, Dylan S., Warman, Anmol, Xiong, Xinyu, Ma, Zhiyuan, Viswanathan, Gayathri, Levitan, Ian M., Rochelle, Lauren K., Staus, Dean P., Snyder, Joshua C., Kahsai, Alem W., Caron, Marc G., Rajagopal, Sudarshan
Format: Artigo
Sprog:Inglês
Udgivet: 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8005335/
https://ncbi.nlm.nih.gov/pubmed/33479120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aay1833
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