Noncanonical scaffolding of G(αi) and β-arrestin by G protein–coupled receptors

Heterotrimeric guanine nucleotide–binding protein (G protein)–coupled receptors (GPCRs) are common drug targets and canonically couple to specific G(α) protein subtypes and β-arrestin adaptor proteins. G protein–mediated signaling and β-arrestin–mediated signaling have been considered separable. We...

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Vydáno v:Science
Hlavní autoři: Smith, Jeffrey S., Pack, Thomas F., Inoue, Asuka, Lee, Claudia, Zheng, Kevin, Choi, Issac, Eiger, Dylan S., Warman, Anmol, Xiong, Xinyu, Ma, Zhiyuan, Viswanathan, Gayathri, Levitan, Ian M., Rochelle, Lauren K., Staus, Dean P., Snyder, Joshua C., Kahsai, Alem W., Caron, Marc G., Rajagopal, Sudarshan
Médium: Artigo
Jazyk:Inglês
Vydáno: 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8005335/
https://ncbi.nlm.nih.gov/pubmed/33479120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aay1833
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