Noncanonical scaffolding of G(αi) and β-arrestin by G protein–coupled receptors

Heterotrimeric guanine nucleotide–binding protein (G protein)–coupled receptors (GPCRs) are common drug targets and canonically couple to specific G(α) protein subtypes and β-arrestin adaptor proteins. G protein–mediated signaling and β-arrestin–mediated signaling have been considered separable. We...

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Publicado no:Science
Main Authors: Smith, Jeffrey S., Pack, Thomas F., Inoue, Asuka, Lee, Claudia, Zheng, Kevin, Choi, Issac, Eiger, Dylan S., Warman, Anmol, Xiong, Xinyu, Ma, Zhiyuan, Viswanathan, Gayathri, Levitan, Ian M., Rochelle, Lauren K., Staus, Dean P., Snyder, Joshua C., Kahsai, Alem W., Caron, Marc G., Rajagopal, Sudarshan
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8005335/
https://ncbi.nlm.nih.gov/pubmed/33479120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aay1833
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