Noncanonical scaffolding of G(αi) and β-arrestin by G protein–coupled receptors

Heterotrimeric guanine nucleotide–binding protein (G protein)–coupled receptors (GPCRs) are common drug targets and canonically couple to specific G(α) protein subtypes and β-arrestin adaptor proteins. G protein–mediated signaling and β-arrestin–mediated signaling have been considered separable. We...

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Veröffentlicht in:Science
Hauptverfasser: Smith, Jeffrey S., Pack, Thomas F., Inoue, Asuka, Lee, Claudia, Zheng, Kevin, Choi, Issac, Eiger, Dylan S., Warman, Anmol, Xiong, Xinyu, Ma, Zhiyuan, Viswanathan, Gayathri, Levitan, Ian M., Rochelle, Lauren K., Staus, Dean P., Snyder, Joshua C., Kahsai, Alem W., Caron, Marc G., Rajagopal, Sudarshan
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8005335/
https://ncbi.nlm.nih.gov/pubmed/33479120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aay1833
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