G Protein-Coupled Receptor Kinase 2 Activates Radixin, Regulating Membrane Protrusion and Motility in Epithelial Cells

Por Kahsai, Alem W., Zhu, Shoutian, Fenteany, Gabriel
Publicado em 2009

Monitoring protein conformational changes and dynamics using stable-isotope labeling and mass spectrometry (CDSiL-MS)

Por Kahsai, Alem W., Rajagopal, Sudarshan, Sun, Jinpeng, Xiao, Kunhong
Publicado no Nat Protoc (2014)

Analogs of Tetrahydroisoquinoline Natural Products That Inhibit Cell Migration and Target Galectin-3 Outside of Its Carbohydrate-binding Site

Por Kahsai, Alem W., Cui, Junru, Kaniskan, H. Ümit, Garner, Philip P., Fenteany, Gabriel
Publicado em 2008

Cucurbitacin I Inhibits Cell Motility by Indirectly Interfering with Actin Dynamics

Por Knecht, David A., LaFleur, Rebecca A., Kahsai, Alem W., Argueta, Christian E., Beshir, Anwar B., Fenteany, Gabriel
Publicado em 2010

Multiple ligand-specific conformations of the β(2)-adrenergic receptor

Por Kahsai, Alem W, Xiao, Kunhong, Rajagopal, Sudarshan, Ahn, Seungkirl, Shukla, Arun K, Sun, Jinpeng, Oas, Terrence G, Lefkowitz, Robert J
Publicado em 2011

Allosteric Nanobodies Reveal the Dynamic Range and Diverse Mechanisms of GPCR Activation

Por Staus, Dean P, Strachan, Ryan T, Manglik, Aashish, Pani, Biswaranjan, Kahsai, Alem W, Kim, Tae Hun, Wingler, Laura M, Ahn, Seungkirl, Chatterjee, Arnab, Masoudi, Ali, Kruse, Andrew C, Pardon, Els, Steyaert, Jan, Weis, William I, Prosser, R. Scott, Kobilka, Brian K, Costa, Tommaso, Lefkowitz, Robert J
Publicado no Nature (2016)

Discovery of β2 Adrenergic Receptor Ligands Using Biosensor Fragment Screening of Tagged Wild-Type Receptor

Por Aristotelous, Tonia, Ahn, Seungkirl, Shukla, Arun K., Gawron, Sylwia, Sassano, Maria F., Kahsai, Alem W., Wingler, Laura M., Zhu, Xiao, Tripathi-Shukla, Prachi, Huang, Xi-Ping, Riley, Jennifer, Besnard, Jérémy, Read, Kevin D., Roth, Bryan L., Gilbert, Ian H., Hopkins, Andrew L., Lefkowitz, Robert J., Navratilova, Iva
Publicado em 2013

Conformationally Selective RNA Aptamers Allosterically Modulate the β(2)-Adrenoceptor

Por Kahsai, Alem W., Wisler, James W., Lee, Jungmin, Ahn, Seungkirl, Cahill, Thomas J., Dennison, S. Moses, Staus, Dean P., Thomsen, Alex R. B., Anasti, Kara M., Pani, Biswaranjan, Wingler, Laura M., Desai, Hemant, Bompiani, Kristin M., Strachan, Ryan T., Qin, Xiaoxia, Alam, S. Munir, Sullenger, Bruce A., Lefkowitz, Robert J.
Publicado no Nat Chem Biol (2016)

Allosteric “beta-blocker” isolated from a DNA-encoded small molecule library

Por Ahn, Seungkirl, Kahsai, Alem W., Pani, Biswaranjan, Wang, Qin-Ting, Zhao, Shuai, Wall, Alissa L., Strachan, Ryan T., Staus, Dean P., Wingler, Laura M., Sun, Lillian D., Sinnaeve, Justine, Choi, Minjung, Cho, Ted, Xu, Thomas T., Hansen, Gwenn M., Burnett, Michael B., Lamerdin, Jane E., Bassoni, Daniel L., Gavino, Bryant J., Husemoen, Gitte, Olsen, Eva K., Franch, Thomas, Costanzi, Stefano, Chen, Xin, Lefkowitz, Robert J.
Publicado no Proc Natl Acad Sci U S A (2017)

Distinct conformations of GPCR–β-arrestin complexes mediate desensitization, signaling, and endocytosis

Por Cahill, Thomas J., Thomsen, Alex R. B., Tarrasch, Jeffrey T., Plouffe, Bianca, Nguyen, Anthony H., Yang, Fan, Huang, Li-Yin, Kahsai, Alem W., Bassoni, Daniel L., Gavino, Bryant J., Lamerdin, Jane E., Triest, Sarah, Shukla, Arun K., Berger, Benjamin, Little, John, Antar, Albert, Blanc, Adi, Qu, Chang-Xiu, Chen, Xin, Kawakami, Kouki, Inoue, Asuka, Aoki, Junken, Steyaert, Jan, Sun, Jin-Peng, Bouvier, Michel, Skiniotis, Georgios, Lefkowitz, Robert J.
Publicado no Proc Natl Acad Sci U S A (2017)

Arrestin-biased AT1R agonism induces acute catecholamine secretion through TRPC3 coupling

Por Liu, Chun-Hua, Gong, Zheng, Liang, Zong-Lai, Liu, Zhi-Xin, Yang, Fan, Sun, Yu-Jing, Ma, Ming-Liang, Wang, Yi-Jing, Ji, Chao-Ran, Wang, Yu-Hong, Wang, Mei-Jie, Cui, Fu-Ai, Lin, Amy, Zheng, Wen-Shuai, He, Dong-Fang, Qu, Chang-xiu, Xiao, Peng, Liu, Chuan-Yong, Thomsen, Alex R. B., Joseph Cahill, Thomas, Kahsai, Alem W., Yi, Fan, Xiao, Kun-Hong, Xue, Tian, Zhou, Zhuan, Yu, Xiao, Sun, Jin-Peng
Publicado no Nat Commun (2017)

Visualization of arrestin recruitment by a G Protein-Coupled Receptor

Por Shukla, Arun K., Westfield, Gerwin H., Xiao, Kunhong, Reis, Rosana I., Huang, Li-Yin, Tripathi-Shukla, Prachi, Qian, Jiang, Li, Sheng, Blanc, Adi, Oleskie, Austin N., Dosey, Anne M., Su, Min, Liang, Cui-Rong, Gu, Ling-Ling, Shan, Jin-Ming, Chen, Xin, Hanna, Rachel, Choi, Minjung, Yao, Xiao Jie, Klink, Bjoern U., Kahsai, Alem W., Sidhu, Sachdev S., Koide, Shohei, Penczek, Pawel A., Kossiakoff, Anthony A., Jr, Virgil L. Woods, Kobilka, Brian K., Skiniotis, Georgios, Lefkowitz, Robert J.
Publicado em 2014