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Allosteric “beta-blocker” isolated from a DNA-encoded small molecule library
The β(2)-adrenergic receptor (β(2)AR) has been a model system for understanding regulatory mechanisms of G-protein–coupled receptor (GPCR) actions and plays a significant role in cardiovascular and pulmonary diseases. Because all known β-adrenergic receptor drugs target the orthosteric binding site...
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Publicado no: | Proc Natl Acad Sci U S A |
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Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
National Academy of Sciences
2017
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5321036/ https://ncbi.nlm.nih.gov/pubmed/28130548 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1620645114 |
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