Molecular mechanism of biased signaling in a prototypical G protein-coupled receptor

Biased signaling, where different ligands that bind to the same G-protein-coupled receptor preferentially trigger distinct signaling pathways, holds great promise for the design of safer and more effective drugs. Its structural mechanism remains unclear, however, hampering efforts to design drugs wi...

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Udgivet i:Science
Main Authors: Suomivuori, Carl-Mikael, Latorraca, Naomi R., Wingler, Laura M., Eismann, Stephan, King, Matthew C., Kleinhenz, Alissa L. W., Skiba, Meredith A., Staus, Dean P., Kruse, Andrew C., Lefkowitz, Robert J., Dror, Ron O.
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7259329/
https://ncbi.nlm.nih.gov/pubmed/32079767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaz0326
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