GPCR-G Protein-β-Arrestin Super-Complex Mediates Sustained G Protein Signaling

Classically, G protein-coupled receptor (GPCR) stimulation promotes G protein signaling at the plasma membrane, followed by rapid β-arrestin-mediated desensitization and receptor internalization into endosomes. However, it has been demonstrated that some GPCRs activate G proteins from within interna...

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Bibliografski detalji
Izdano u:Cell
Glavni autori: Thomsen, Alex R.B., Plouffe, Bianca, Cahill, Thomas J., Shukla, Arun K., Tarrasch, Jeffrey T., Dosey, Annie M., Kahsai, Alem W., Strachan, Ryan T., Pani, Biswaranjan, Mahoney, Jacob P., Huang, Liyin, Breton, Billy, Heydenreich, Franziska M., Sunahara, Roger K., Skiniotis, Georgios, Bouvier, Michel, Lefkowitz, Robert J.
Format: Artigo
Jezik:Inglês
Izdano: 2016
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5418658/
https://ncbi.nlm.nih.gov/pubmed/27499021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2016.07.004
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