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O-GlcNAcase fragment discovery with fluorescence polarimetry

The attachment of the sugar D-N-acetylglucosamine (GlcNAc) with to specific serine and threonine residues on proteins is referred to as protein O-GlcNAcylation. O-GlcNAc transferase (OGT) is the enzyme responsible for carrying out the modification while O-GlcNAcase (OGA) reverses it. Protein O-GlcNA...

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Detalhes bibliográficos
Publicado no:ACS Chem Biol
Main Authors: Borodkin, Vladimir S., Rafie, Karim, Selvan, Nithya, Aristotelous, Tonia, Navratilova, Iva, Ferenbach, Andrew T., van Aalten, Daan M. F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7611149/
https://ncbi.nlm.nih.gov/pubmed/29641181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.8b00183
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