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Screening-based discovery of drug-like O-GlcNAcase inhibitor scaffolds
O-GlcNAcylation is an essential posttranslational modification in metazoa. Modulation of O-GlcNAc levels with small molecule inhibitors of O-GlcNAc hydrolase (OGA) is a useful strategy to probe the role of this modification in a range of cellular processes. Here we report the discovery of novel, low...
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| Hauptverfasser: | , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Elsevier Science B.V
2010
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2828546/ https://ncbi.nlm.nih.gov/pubmed/20026047 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2009.12.020 |
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