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GlcNAcstatins are nanomolar inhibitors of human O-GlcNAcase inducing cellular hyper-O-GlcNAcylation

O-GlcNAcylation is an essential, dynamic and inducible post-translational glycosylation of cytosolic proteins in metazoa and can show interplay with protein phosphorylation. Inhibition of OGA (O-GlcNAcase), the enzyme that removes O-GlcNAc from O-GlcNAcylated proteins, is a useful strategy to probe...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Dorfmueller, Helge C., Borodkin, Vladimir S., Schimpl, Marianne, van Aalten, Daan M. F.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Portland Press Ltd. 2009
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2691177/
https://ncbi.nlm.nih.gov/pubmed/19275764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20090110
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