GlcNAcstatin - a picomolar, selective O-GlcNAcase inhibitor that modulates intracellular O-GlcNAcylation levels

Many phosphorylation signal transduction pathways in the eukaryotic cell are modulated by posttranslational modification of specific serines/threonines with N-acetylglucosamine (O-GlcNAc). Levels of O-GlcNAc on key proteins regulate biological processes as diverse as the cell cycle, insulin signalli...

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Vydáno v:J Am Chem Soc
Hlavní autoři: Dorfmueller, Helge C., Borodkin, Vladimir S., Schimpl, Marianne, Shepherd, Sharon M., Shpiro, Natalia A., van Aalten, Daan M. F.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2006
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7116141/
https://ncbi.nlm.nih.gov/pubmed/17177381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja066743n
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