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O-GlcNAc transferase invokes nucleotide sugar pyrophosphate participation in catalysis
Protein O-GlcNAcylation is an essential post-translational modification on hundreds of intracellular proteins in metazoa, catalyzed by O-GlcNAc transferase using unknown mechanisms of transfer and substrate recognition. Through crystallographic snapshots and mechanism-inspired chemical probes, we de...
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| Hoofdauteurs: | , , , , , , , , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2012
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3509171/ https://ncbi.nlm.nih.gov/pubmed/23103942 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1108 |
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