Proteolysis of HCF-1 by Ser/Thr glycosylation-incompetent O-GlcNAc transferase:UDP-GlcNAc complexes

In complex with the cosubstrate UDP-N-acetylglucosamine (UDP-GlcNAc), O-linked-GlcNAc transferase (OGT) catalyzes Ser/Thr O-GlcNAcylation of many cellular proteins and proteolysis of the transcriptional coregulator HCF-1. Such a dual glycosyltransferase–protease activity, which occurs in the same ac...

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Bibliographic Details
Published in:Genes Dev
Main Authors: Kapuria, Vaibhav, Röhrig, Ute F., Bhuiyan, Tanja, Borodkin, Vladimir S., van Aalten, Daan M.F., Zoete, Vincent, Herr, Winship
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 2016
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4840301/
https://ncbi.nlm.nih.gov/pubmed/27056667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.275925.115
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