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Bisubstrate UDP–peptide conjugates as human O-GlcNAc transferase inhibitors
Inhibitors of OGT (O-GlcNAc transferase) are valuable tools to study the cell biology of protein O-GlcNAcylation. We report OGT bisubstrate-linked inhibitors (goblins) in which the acceptor serine in the peptide VTPVSTA is covalently linked to UDP, eliminating the GlcNAc pyranoside ring. Goblin1 co-...
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| 主要な著者: | , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Portland Press Ltd.
2014
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3927924/ https://ncbi.nlm.nih.gov/pubmed/24256146 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20131272 |
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