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Bisubstrate UDP–peptide conjugates as human O-GlcNAc transferase inhibitors
Inhibitors of OGT (O-GlcNAc transferase) are valuable tools to study the cell biology of protein O-GlcNAcylation. We report OGT bisubstrate-linked inhibitors (goblins) in which the acceptor serine in the peptide VTPVSTA is covalently linked to UDP, eliminating the GlcNAc pyranoside ring. Goblin1 co-...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Portland Press Ltd.
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3927924/ https://ncbi.nlm.nih.gov/pubmed/24256146 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20131272 |
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