Bisubstrate UDP–peptide conjugates as human O-GlcNAc transferase inhibitors

Inhibitors of OGT (O-GlcNAc transferase) are valuable tools to study the cell biology of protein O-GlcNAcylation. We report OGT bisubstrate-linked inhibitors (goblins) in which the acceptor serine in the peptide VTPVSTA is covalently linked to UDP, eliminating the GlcNAc pyranoside ring. Goblin1 co-...

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Tallennettuna:
Bibliografiset tiedot
Päätekijät: Borodkin, Vladimir S., Schimpl, Marianne, Gundogdu, Mehmet, Rafie, Karim, Dorfmueller, Helge C., Robinson, David A., vanAalten, Daan M. F.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Portland Press Ltd. 2014
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3927924/
https://ncbi.nlm.nih.gov/pubmed/24256146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20131272
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