The conserved threonine-rich region of the HCF-1(PRO) repeat activates promiscuous OGT:UDP-GlcNAc glycosylation and proteolysis activities

O-Linked GlcNAc transferase (OGT) possesses dual glycosyltransferase–protease activities. OGT thereby stably glycosylates serines and threonines of numerous proteins and, via a transient glutamate glycosylation, cleaves a single known substrate—the so-called HCF-1(PRO) repeat of the transcriptional...

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Bibliografiska uppgifter
I publikationen:J Biol Chem
Huvudupphovsmän: Kapuria, Vaibhav, Röhrig, Ute F., Waridel, Patrice, Lammers, Fabienne, Borodkin, Vladimir S., van Aalten, Daan M. F., Zoete, Vincent, Herr, Winship
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2018
Ämnen:
Glycobiology and Extracellular Matrices
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6240873/
https://ncbi.nlm.nih.gov/pubmed/30224358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.004185
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