Fragment-derived inhibitors of human N-myristoyltransferase block capsid assembly and replication of the common cold virus

Rhinoviruses are the pathogens most often responsible for the common cold, and are a frequent cause of exacerbations in asthma, chronic obstructive pulmonary disease and cystic fibrosis. Here we report discovery of IMP-1088, a picomolar dual inhibitor of the human N-myristoyltransferases NMT1 and NM...

Volledige beschrijving

Bewaard in:
Bibliografische gegevens
Gepubliceerd in:Nat Chem
Hoofdauteurs: Mousnier, Aurélie, Bell, Andrew S., Swieboda, Dawid P., Morales-Sanfrutos, Julia, Pérez-Dorado, Inmaculada, Brannigan, James A., Newman, Joseph, Ritzefeld, Markus, Hutton, Jennie A., Guedán, Anabel, Asfor, Amin A., Robinson, Sean W., Hopkins-Navratilova, Iva, Wilkinson, Anthony J., Johnston, Sebastian L., Leatherbarrow, Robin J., Tuthill, Tobias J., Solari, Roberto, Tate, Edward W.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2018
Onderwerpen:
Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6015761/
https://ncbi.nlm.nih.gov/pubmed/29760414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41557-018-0039-2
Tags: Voeg label toe
Geen labels, Wees de eerste die dit record labelt!

Gelijkaardige items