Novel Thienopyrimidine Inhibitors of Leishmania N-Myristoyltransferase with On-Target Activity in Intracellular Amastigotes

[Image: see text] The leishmaniases, caused by Leishmania species of protozoan parasites, are neglected tropical diseases with millions of cases worldwide. Current therapeutic approaches are limited by toxicity, resistance, and cost. N-Myristoyltransferase (NMT), an enzyme ubiquitous and essential i...

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Xehetasun bibliografikoak
Argitaratua izan da:J Med Chem
Egile Nagusiak: Bell, Andrew S., Yu, Zhiyong, Hutton, Jennie A., Wright, Megan H., Brannigan, James A., Paape, Daniel, Roberts, Shirley M., Sutherell, Charlotte L., Ritzefeld, Markus, Wilkinson, Anthony J., Smith, Deborah F., Leatherbarrow, Robin J., Tate, Edward W.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Chemical Society 2020
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7383931/
https://ncbi.nlm.nih.gov/pubmed/32575985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.0c00570
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